The Hochschild Lab

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Recent Publications - Since 2002:

Rao X, Deighan P, Hua Z, Hu X, Wang J, Luo M, Wang J, Liang Y, Zhong G, Hochschild A, Shen L. A regulator from Chlamydia trachomatis modulates the activity of RNA polymerase through direct interaction with the β subunit and the primary σ subunit. Genes Dev. 2009, in press.

Yuan AH, Nickels BE, Hochschild A. The bacteriophage T4 AsiA protein contacts the β-flap domain of RNA polymerase. Proc Natl Acad Sci U S A. 2009; 106(16):6597-602.

Hochschild A, Lewis M. The bacteriophage lambda CI protein finds an asymmetric solution. Curr Opin Struct Biol. 2009; 19(1):79-86.

Yuan AH, Gregory BD, Sharp JS, McCleary KD, Dove SL, Hochschild A. Rsd family proteins make simultaneous interactions with regions 2 and 4 of the primary sigma factor. Mol Microbiol. 2008; 70(5):1136-51.

Deighan P, Diez CM, Leibman M, Hochschild A, Nickels BE. The bacteriophage lambda Q antiterminator protein contacts the β-flap domain of RNA polymerase. Proc Natl Acad Sci U S A. 2008;105(40):15305-10.

Stayrook S, Jaru-Ampornpan P, Ni J, Hochschild A, Lewis M. Crystal structure of the lambda repressor and a model for pairwise cooperative operator binding. Nature. 2008; 452(7190):1022-5.

Hochschild A. Gene-specific regulation by a transcript cleavage factor: facilitating promoter escape. J Bacteriol. 2007; 189(24):8769-71.

Leibman M and Hochschild A. A σ-core interaction of the RNA polymerase holoenzyme that enhances promoter escape. EMBO J. 2007; 26(6):1579-90.

Deighan P and Hochschild A. The bacteriophage λ Q antiterminator protein regulates late gene expression as a stable component of the transcription elongation complex. Mol. Microbiol. 2007; 63: 911-920.

Nickels BE, Roberts CW, Roberts JW, and Hochschild A. RNA-mediated destabilization of the σ70 region 4/ß flap interaction facilitates engagement of RNA polymerase holoenzyme by the Q antiterminator. Mol. Cell 2006; 24: 457-468.

Deighan P and Hochschild A. Conformational Toggle triggers a modulator of RNA polymerase activity. TiBs 2006; 31: 424-426.

Pinkett HW, Shearwin KE, Stayrook S, Dodd IB, Burr T, Hochschild A, Egan JB, Lewis M. The structural basis of cooperative regulation at an alternate genetic switch. Mol. Cell 2006; 21:605-15.

Deaconescu AM, Chambers AL, Smith AJ, Nickels BE, Hochschild A, Savery NJ, Darst SA. Structural basis for bacterial transcription-coupled DNA repair. Cell 2006; 124:507-20.





Ann Hochschild - Department of Microbiology & Molecular Genetics
Harvard Medical School - 200 Longwood Avenue - Boston, MA 02115

Office: 617-432-1986 - Fax: 617-738-7664
Email: ahochschild@hms.harvard.edu