The Hochschild Lab

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Recent Publications - Since 2002:

Leibman M and Hochschild A. A σ-core interaction of the RNA polymerase holoenzyme that enhances promoter escape. EMBO J. 2007; in press.

Deighan P and Hochschild A. The bacteriophage λ Q antiterminator protein regulates late gene expression as a stable component of the transcription elongation complex. Mol. Microbiol. 2007; 63: 911-920.

Nickels BE, Roberts CW, Roberts JW, and Hochschild A. RNA-mediated destabilization of the σ70 region 4/ß flap interaction facilitates engagement of RNA polymerase holoenzyme by the Q antiterminator. Mol. Cell 2006; 24: 457-468.

Deighan P and Hochschild A. Conformational Toggle triggers a modulator of RNA polymerase activity. TiBs 2006; 31: 424-426.

Pinkett HW, Shearwin KE, Stayrook S, Dodd IB, Burr T, Hochschild A, Egan JB, Lewis M. The structural basis of cooperative regulation at an alternate genetic switch. Mol. Cell 2006; 21:605-15.

Deaconescu AM, Chambers AL, Smith AJ, Nickels BE, Hochschild A, Savery NJ, Darst SA. Structural basis for bacterial transcription-coupled DNA repair. Cell 2006; 124:507-20.

Gregory BD, Deighan P, Hochschild A. An artificial activator that contacts a normally occluded surface of the RNA polymerase holoenzyme. J. Mol. Biol. 2005; 353:497-506.

Gregory BD, Nickels BE, Darst SA, Hochschild A. An altered-specificity DNA-binding mutant of Escherichia coli σ70 facilitates the analysis of σ70 function in vivo. Mol. Microbiol. 2005; 56:1208-19.

Nickels BE, Garrity SJ, Mekler V, Minakhin L, Severinov K, Ebright RH, Hochschild A. The interaction between σ70 and the ß-flap of Escherichia coli RNA polymerase inhibits extension of nascent RNA during early elongation. Proc. Natl. Acad. Sci. USA 2005; 102:4488-93.

Sun L, Dove SL, Panaghie G, deHaseth PL, and Hochschild A. An RNA polymerase mutant deficient in DNA melting facilitates study of activation mechanism. J. Mol. Biol. 2004; 343:1171-1182.

Nickels BE and Hochschild A. Regulation of RNA polymerase through the secondary channel. Cell 2004; 118:281-4.




Ann Hochschild - Department of Microbiology & Molecular Genetics
Harvard Medical School - 200 Longwood Avenue - Boston, MA 02115

Office: 617-432-1986 - Fax: 617-738-7664
Email: ahochschild@hms.harvard.edu